The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SRPRB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRPRB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRPRB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:133,661,440–133,662,508 | 143.9 kb | Distal (>10kb) Multiome | 728 | |
| chr3:133,805,616–133,806,520 | 51 bp | At TSS Multiome | 710 | |
| chr3:133,894,751–133,896,433 | 90.0 kb | Distal (>10kb) Multiome | 424 | |
| chr3:133,927,020–133,928,082 | 121.8 kb | Distal (>10kb) Multiome | 363 | |
| chr3:133,988,622–133,989,245 | 183.1 kb | Distal (>10kb) Multiome | 246 | |
| chr3:134,028,965–134,030,691 | 224.3 kb | Distal (>10kb) Multiome | 495 |
Genomic view of the SRPRB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.