Enables FAD binding activity and squalene monooxygenase activity. Involved in lipid droplet formation; regulation of cell population proliferation; and sterol biosynthetic process. Located in intracellular membrane-bounded organelle and membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SQLE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SQLE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SQLE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:124,538,847–124,539,474 | 459.4 kb | Distal (>10kb) Multiome HiCAR | 921 | |
| chr8:124,726,992–124,728,984 | 269.9 kb | Distal (>10kb) Multiome | 609 | |
| chr8:124,830,627–124,831,574 | 167.4 kb | Distal (>10kb) Multiome | 135 | |
| chr8:124,908,848–124,909,459 | 89.3 kb | Distal (>10kb) Multiome | 23 | |
| chr8:124,963,890–124,964,452 | 34.4 kb | Distal (>10kb) Multiome | 165 | |
| chr8:124,973,135–124,973,609 | 25.2 kb | Distal (>10kb) Multiome | 684 | |
| chr8:124,997,595–124,999,115 | 143 bp | At TSS Multiome | 836 | |
| chr8:125,091,367–125,092,149 | 93.2 kb | Distal (>10kb) Multiome | 874 |
Genomic view of the SQLE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.