Enables DNA binding activity; histone binding activity; and histone chaperone activity. Involved in heterochromatin formation; nucleosome assembly; and regulation of DNA-templated transcription. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SPTY2D1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPTY2D1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPTY2D1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:18,393,759–18,396,665 | 238.1 kb | Distal (>10kb) Multiome | 1203 | |
| chr11:18,526,292–18,527,325 | 107.5 kb | Distal (>10kb) Multiome | 1012 | |
| chr11:18,588,293–18,589,047 | 45.6 kb | Distal (>10kb) Multiome | 837 | |
| chr11:18,633,863–18,635,078 | 178 bp | At TSS Multiome | 834 | |
| chr11:18,698,354–18,699,356 | 64.4 kb | Distal (>10kb) Multiome | 586 | |
| chr11:18,720,706–18,722,495 | 86.9 kb | Distal (>10kb) Multiome | 447 | |
| chr11:18,790,876–18,792,822 | 157.4 kb | Distal (>10kb) Multiome | 294 | |
| chr11:18,900,169–18,900,999 | 266.2 kb | Distal (>10kb) Multiome | 195 |
Genomic view of the SPTY2D1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.