Predicted to enable LBD domain binding activity and metal ion binding activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in cell adhesion. Predicted to act upstream of or within negative regulation of amyloid-beta formation; positive regulation of amyloid precursor protein catabolic process; and positive regulation of protein processing. Located in collagen-containing extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SPON1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPON1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPON1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:13,667,826–13,669,520 | 294.2 kb | Distal (>10kb) Multiome | 653 | |
| chr11:13,777,387–13,777,953 | 185.1 kb | Distal (>10kb) Multiome | 153 | |
| chr11:13,955,959–13,956,395 | 6.3 kb | Proximal (<10kb) | 131 | |
| chr11:13,962,160–13,964,858 | 40 bp | At TSS Multiome | 311 | |
| chr11:13,971,061–13,971,249 | 8.3 kb | Proximal (<10kb) | 113 | |
| chr11:14,075,211–14,076,080 | 113.0 kb | Distal (>10kb) Multiome | 190 |
Genomic view of the SPON1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.