Involved in signal peptide processing and viral protein processing. Located in endoplasmic reticulum membrane. Part of signal peptidase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SPCS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPCS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPCS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:176,065,262–176,066,534 | 254.0 kb | Distal (>10kb) Multiome | 484 | |
| chr4:176,194,750–176,196,011 | 124.4 kb | Distal (>10kb) Multiome | 672 | |
| chr4:176,299,830–176,300,857 | 19.7 kb | Distal (>10kb) Multiome | 90 | |
| chr4:176,319,103–176,320,877 | 75 bp | At TSS Multiome | 848 |
Genomic view of the SPCS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.