Predicted to enable peptidase activity. Involved in signal peptide processing. Located in endoplasmic reticulum membrane. Part of signal peptidase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SPCS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPCS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPCS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:74,731,155–74,731,658 | 217.8 kb | Distal (>10kb) Multiome | 131 | |
| chr11:74,748,226–74,749,731 | 200.4 kb | Distal (>10kb) Multiome | 854 | |
| chr11:74,948,631–74,949,595 | 86 bp | At TSS Multiome | 870 | |
| chr11:74,988,546–74,989,331 | 39.5 kb | Distal (>10kb) Multiome | 661 | |
| chr11:75,240,428–75,242,358 | 292.5 kb | Distal (>10kb) Multiome | 618 |
Genomic view of the SPCS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.