Predicted to contribute to microtubule binding activity. Involved in attachment of spindle microtubules to kinetochore. Located in kinetochore; nucleolus; and nucleoplasm. Part of Ndc80 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SPC24. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPC24 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPC24, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:10,870,403–10,872,620 | 284.6 kb | Distal (>10kb) Multiome | 714 | |
| chr19:10,928,331–10,929,395 | 227.1 kb | Distal (>10kb) Multiome | 860 | |
| chr19:10,960,232–10,961,863 | 194.9 kb | Distal (>10kb) Multiome | 1016 | |
| chr19:11,089,041–11,091,015 | 66.5 kb | Distal (>10kb) Multiome | 964 | |
| chr19:11,137,551–11,138,233 | 17.9 kb | Distal (>10kb) Multiome | 584 | |
| chr19:11,155,520–11,156,298 | 92 bp | At TSS Multiome | 754 | |
| chr19:11,196,759–11,198,184 | 41.9 kb | Distal (>10kb) Multiome | 728 | |
| chr19:11,243,345–11,243,968 | 87.7 kb | Distal (>10kb) Multiome | 448 | |
| chr19:11,262,060–11,262,653 | 106.6 kb | Distal (>10kb) Multiome | 406 | |
| chr19:11,339,100–11,339,837 | 183.8 kb | Distal (>10kb) Multiome | 506 | |
| chr19:11,346,053–11,346,958 | 190.7 kb | Distal (>10kb) Multiome | 676 | |
| chr19:11,355,078–11,355,735 | 199.6 kb | Distal (>10kb) Multiome | 382 | |
| chr19:11,361,368–11,362,625 | 205.8 kb | Distal (>10kb) Multiome | 256 | |
| chr19:11,374,474–11,375,717 | 219.1 kb | Distal (>10kb) Multiome | 866 | |
| chr19:11,380,761–11,382,262 | 225.5 kb | Distal (>10kb) Multiome | 798 | |
| chr19:11,382,830–11,384,509 | 228.5 kb | Distal (>10kb) Multiome | 761 | |
| chr19:11,418,061–11,419,498 | 262.8 kb | Distal (>10kb) Multiome | 421 | |
| chr19:11,420,614–11,422,979 | 266.3 kb | Distal (>10kb) Multiome | 507 | |
| chr19:11,434,817–11,436,365 | 279.5 kb | Distal (>10kb) Multiome | 927 |
Genomic view of the SPC24 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.