Enables identical protein binding activity. Predicted to be involved in spermatogenesis. Predicted to act upstream of or within actin polymerization or depolymerization; positive regulation of cAMP-dependent protein kinase activity; and positive regulation of cAMP/PKA signal transduction. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SPATC1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPATC1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPATC1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:45,970,520–45,971,289 | 213.7 kb | Distal (>10kb) Multiome | 325 | |
| chr21:45,973,174–45,975,630 | 210.5 kb | Distal (>10kb) Multiome | 597 | |
| chr21:45,981,076–45,982,605 | 202.9 kb | Distal (>10kb) Multiome | 580 | |
| chr21:46,097,574–46,098,972 | 86.4 kb | Distal (>10kb) Multiome | 294 | |
| chr21:46,153,138–46,153,696 | 31.0 kb | Distal (>10kb) Multiome | 515 | |
| chr21:46,184,069–46,184,514 | at TSS | At TSS | 298 | |
| chr21:46,184,645–46,185,202 | 226 bp | At TSS Multiome | 334 | |
| chr21:46,228,249–46,230,022 | 44.5 kb | Distal (>10kb) Multiome | 833 | |
| chr21:46,285,753–46,286,753 | 101.9 kb | Distal (>10kb) Multiome | 983 | |
| chr21:46,323,408–46,325,506 | 139.6 kb | Distal (>10kb) Multiome | 952 | |
| chr21:46,457,952–46,459,810 | 274.3 kb | Distal (>10kb) Multiome | 880 |
Genomic view of the SPATC1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.