This gene encodes a regulatory protein that is involved in the positive regulation of ras proteins. Mutations in this gene are associated with Noonan Syndrome-9. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for SOS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SOS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SOS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:50,000,183–50,001,939 | 230.2 kb | Distal (>10kb) Multiome | 669 | |
| chr14:50,116,214–50,116,984 | 115.0 kb | Distal (>10kb) Multiome | 818 | |
| chr14:50,226,019–50,226,227 | 5.3 kb | Proximal (<10kb) | 90 | |
| chr14:50,231,069–50,232,486 | 241 bp | At TSS Multiome | 823 | |
| chr14:50,311,389–50,313,095 | 80.7 kb | Distal (>10kb) Multiome | 986 | |
| chr14:50,396,285–50,397,366 | 165.3 kb | Distal (>10kb) Multiome | 782 |
Genomic view of the SOS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.