This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for SORBS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SORBS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SORBS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:95,263,812–95,265,078 | 296.7 kb | Distal (>10kb) Multiome | 233 | |
| chr10:95,289,276–95,289,909 | 271.9 kb | Distal (>10kb) Multiome | 302 | |
| chr10:95,290,409–95,291,390 | 270.3 kb | Distal (>10kb) Multiome | 671 | |
| chr10:95,305,545–95,306,494 | 255.4 kb | Distal (>10kb) Multiome | 125 | |
| chr10:95,312,976–95,313,538 | 248.2 kb | Distal (>10kb) Multiome | 108 | |
| chr10:95,332,677–95,333,436 | 228.4 kb | Distal (>10kb) Multiome | 42 | |
| chr10:95,425,771–95,426,669 | 135.2 kb | Distal (>10kb) Multiome | 202 | |
| chr10:95,559,449–95,559,873 | 1.5 kb | Proximal (<10kb) | 120 | |
| chr10:95,560,414–95,561,730 | 59 bp | At TSS Multiome | 707 | |
| chr10:95,655,874–95,657,154 | 95.3 kb | Distal (>10kb) Multiome | 834 | |
| chr10:95,693,285–95,694,389 | 132.7 kb | Distal (>10kb) Multiome | 744 | |
| chr10:95,840,547–95,841,469 | 279.5 kb | Distal (>10kb) Multiome | 21 |
Genomic view of the SORBS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.