Predicted to enable phosphorylation-dependent protein binding activity; signaling adaptor activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in insulin receptor signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of neuron migration. Predicted to act upstream of or within brain development; fat cell differentiation; and protein ubiquitination. Located in cytosol. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SOCS7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SOCS7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SOCS7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:38,256,154–38,256,660 | 95.6 kb | Distal (>10kb) Multiome | 119 | |
| chr17:38,349,211–38,349,426 | 2.4 kb | Proximal (<10kb) | 295 | |
| chr17:38,350,586–38,350,846 | 996 bp | At TSS | 34 | |
| chr17:38,351,522–38,352,472 | 35 bp | At TSS Multiome | 809 | |
| chr17:38,352,588–38,353,383 | 745 bp | At TSS | 298 | |
| chr17:38,414,746–38,415,878 | 63.0 kb | Distal (>10kb) Multiome HiCAR | 792 | |
| chr17:38,428,075–38,428,868 | 76.6 kb | Distal (>10kb) Multiome | 298 | |
| chr17:38,453,611–38,454,219 | 102.0 kb | Distal (>10kb) Multiome | 168 | |
| chr17:38,509,961–38,510,926 | 158.7 kb | Distal (>10kb) Multiome | 409 | |
| chr17:38,558,106–38,558,652 | 206.5 kb | Distal (>10kb) Multiome | 631 | |
| chr17:38,559,205–38,559,900 | 207.8 kb | Distal (>10kb) Multiome | 598 | |
| chr17:38,572,553–38,573,232 | 221.1 kb | Distal (>10kb) Multiome | 231 | |
| chr17:38,604,448–38,605,250 | 253.1 kb | Distal (>10kb) Multiome | 375 | |
| chr17:38,605,359–38,606,888 | 254.6 kb | Distal (>10kb) Multiome | 781 | |
| chr17:38,609,172–38,610,061 | 257.8 kb | Distal (>10kb) Multiome | 229 |
Genomic view of the SOCS7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.