SOCS5

suppressor of cytokine signaling 5 | CIS6, CISH6, Cish5, KIAA0671, SOCS-5

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]

Biological processes 24 terms

cell surface receptor signaling pathway via JAK-STAT (GO:0007259)cellular response to low-density lipoprotein particle stimulus (GO:0071404)cytokine-mediated signaling pathway (GO:0019221)cytokine-mediated signaling pathway (GO:0019221)cytokine-mediated signaling pathway (GO:0019221)cytosol (GO:0005829)epidermal growth factor receptor binding (GO:0005154)epidermal growth factor receptor signaling pathway (GO:0007173)intracellular signal transduction (GO:0035556)negative regulation of T-helper 2 cell differentiation (GO:0045629)negative regulation of T-helper 2 cell differentiation (GO:0045629)negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)negative regulation of inflammatory response (GO:0050728)negative regulation of interleukin-6 production (GO:0032715)negative regulation of monocyte chemotactic protein-1 production (GO:0071638)negative regulation of signal transduction (GO:0009968)positive regulation of T-helper 1 cell differentiation (GO:0045627)positive regulation of T-helper 1 cell differentiation (GO:0045627)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)protein binding (GO:0005515)protein ubiquitination (GO:0016567)receptor tyrosine kinase binding (GO:0030971)vascular endothelial cell response to fluid shear stress (GO:0097699)

Expression (TPM)

TFs regulating SOCS5 0 TFs

Transcription factors with Perturb-seq knockdown data for SOCS5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SOCS5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SOCS5

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SOCS5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:46,499,830–46,500,537	199.0 kb	Distal (>10kb) Multiome	657
chr2:46,541,624–46,542,151	157.3 kb	Distal (>10kb) Multiome	610
chr2:46,542,212–46,544,274	156.8 kb	Distal (>10kb) Multiome	785
chr2:46,616,071–46,617,512	82.2 kb	Distal (>10kb) Multiome	955
chr2:46,698,279–46,700,093	290 bp	At TSS Multiome	974
chr2:46,704,551–46,705,027	5.5 kb	Proximal (<10kb) Multiome	109
chr2:46,915,163–46,916,556	216.6 kb	Distal (>10kb) Multiome	931
chr2:46,940,391–46,942,183	242.0 kb	Distal (>10kb) Multiome	931
chr2:46,986,672–46,987,498	287.9 kb	Distal (>10kb) Multiome	630

Genome Browser

Genomic view of the SOCS5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.