The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SOCS4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SOCS4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SOCS4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:54,773,202–54,773,766 | 253.9 kb | Distal (>10kb) Multiome | 548 | |
| chr14:54,805,654–54,806,307 | 221.2 kb | Distal (>10kb) Multiome | 376 | |
| chr14:54,901,803–54,903,430 | 124.3 kb | Distal (>10kb) Multiome | 886 | |
| chr14:55,026,752–55,027,732 | 13 bp | At TSS Multiome | 918 | |
| chr14:55,051,004–55,052,455 | 24.5 kb | Distal (>10kb) Multiome | 1079 | |
| chr14:55,103,022–55,103,627 | 76.1 kb | Distal (>10kb) Multiome | 700 | |
| chr14:55,128,954–55,130,369 | 102.1 kb | Distal (>10kb) Multiome | 569 | |
| chr14:55,191,089–55,192,110 | 164.5 kb | Distal (>10kb) Multiome | 702 | |
| chr14:55,270,885–55,272,249 | 244.1 kb | Distal (>10kb) Multiome | 901 | |
| chr14:55,275,685–55,276,150 | 248.6 kb | Distal (>10kb) Multiome | 15 |
Genomic view of the SOCS4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.