This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SOCS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SOCS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SOCS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:78,127,361–78,129,338 | 231.3 kb | Distal (>10kb) Multiome | 909 | |
| chr17:78,140,136–78,141,130 | 219.5 kb | Distal (>10kb) Multiome | 594 | |
| chr17:78,168,117–78,169,078 | 191.6 kb | Distal (>10kb) Multiome | 738 | |
| chr17:78,186,463–78,187,739 | 172.9 kb | Distal (>10kb) Multiome | 1021 | |
| chr17:78,213,978–78,214,702 | 145.9 kb | Distal (>10kb) Multiome | 902 | |
| chr17:78,250,689–78,251,651 | 109.0 kb | Distal (>10kb) Multiome | 714 | |
| chr17:78,254,178–78,254,892 | 105.5 kb | Distal (>10kb) Multiome | 860 | |
| chr17:78,270,255–78,273,257 | 87.6 kb | Distal (>10kb) Multiome HiCAR | 667 | |
| chr17:78,278,089–78,278,902 | 81.6 kb | Distal (>10kb) Multiome HiCAR | 225 | |
| chr17:78,313,762–78,314,579 | 45.8 kb | Distal (>10kb) Multiome | 636 | |
| chr17:78,341,604–78,342,374 | 18.1 kb | Distal (>10kb) Multiome | 423 | |
| chr17:78,351,461–78,352,240 | 7.8 kb | Proximal (<10kb) | 383 | |
| chr17:78,352,598–78,353,774 | 7.0 kb | Proximal (<10kb) Multiome | 687 | |
| chr17:78,356,201–78,356,710 | 3.4 kb | Proximal (<10kb) | 319 | |
| chr17:78,358,869–78,361,525 | 180 bp | At TSS Multiome | 898 | |
| chr17:78,364,478–78,364,796 | 4.4 kb | Proximal (<10kb) | 85 | |
| chr17:78,365,478–78,366,101 | 5.8 kb | Proximal (<10kb) Multiome | 305 | |
| chr17:78,378,324–78,379,091 | 18.5 kb | Distal (>10kb) Multiome | 921 |
Genomic view of the SOCS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.