Transcription factors with Perturb-seq knockdown data for SOCS2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SOCS2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SOCS2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:93,376,338–93,378,831 | 193.0 kb | Distal (>10kb) Multiome | 827 | |
| chr12:93,441,175–93,442,781 | 128.8 kb | Distal (>10kb) Multiome | 926 | |
| chr12:93,467,156–93,468,248 | 103.3 kb | Distal (>10kb) Multiome | 844 | |
| chr12:93,564,287–93,564,590 | 6.3 kb | Proximal (<10kb) | 179 | |
| chr12:93,569,457–93,573,628 | 43 bp | At TSS Multiome | 1052 | |
| chr12:93,677,025–93,678,145 | 106.6 kb | Distal (>10kb) Multiome | 999 | |
| chr12:93,741,675–93,742,916 | 171.5 kb | Distal (>10kb) Multiome HiCAR | 726 | |
| chr12:94,101,224–94,102,767 | 531.6 kb | Distal (>10kb) Multiome HiCAR | 674 |
Genomic view of the SOCS2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.