The protein encoded by this gene is a sorting nexin that is found in the cytoplasm, where it interacts with membrane-bound phosphatidylinositol 3-phosphate. The encoded protein may play a role in intracellular trafficking. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for SNX22. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNX22 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNX22, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:64,045,892–64,046,997 | 105.2 kb | Distal (>10kb) Multiome | 442 | |
| chr15:64,093,386–64,094,387 | 57.8 kb | Distal (>10kb) Multiome | 765 | |
| chr15:64,095,741–64,096,612 | 55.7 kb | Distal (>10kb) Multiome | 839 | |
| chr15:64,143,425–64,143,630 | 8.1 kb | Proximal (<10kb) | 59 | |
| chr15:64,146,930–64,147,642 | 4.1 kb | Proximal (<10kb) | 403 | |
| chr15:64,151,111–64,152,828 | 93 bp | At TSS Multiome | 586 | |
| chr15:64,152,948–64,154,154 | 2.0 kb | Proximal (<10kb) Multiome | 593 | |
| chr15:64,162,530–64,163,834 | 11.5 kb | Distal (>10kb) Multiome | 876 | |
| chr15:64,355,477–64,356,649 | 204.5 kb | Distal (>10kb) Multiome | 748 | |
| chr15:64,381,037–64,381,737 | 229.8 kb | Distal (>10kb) Multiome | 630 | |
| chr15:64,387,554–64,388,126 | 236.1 kb | Distal (>10kb) Multiome | 1137 | |
| chr15:64,430,220–64,430,746 | 278.7 kb | Distal (>10kb) Multiome | 350 |
Genomic view of the SNX22 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.