This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The protein encoded by this gene associates with late endosome membranes as is involved in tubule formation, cholesterol transport, and transport of tetraspanin CD81. The encoded protein also inhibits cell migration and tumorigenesis. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for SNX16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNX16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNX16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:81,630,496–81,631,299 | 211.8 kb | Distal (>10kb) Multiome | 326 | |
| chr8:81,685,772–81,686,622 | 156.6 kb | Distal (>10kb) Multiome | 915 | |
| chr8:81,720,515–81,721,822 | 121.5 kb | Distal (>10kb) Multiome | 750 | |
| chr8:81,731,713–81,733,032 | 110.2 kb | Distal (>10kb) Multiome | 732 | |
| chr8:81,895,652–81,897,396 | 53.3 kb | Distal (>10kb) Multiome | 316 | |
| chr8:81,897,889–81,899,280 | 55.4 kb | Distal (>10kb) Multiome | 138 | |
| chr8:81,903,428–81,904,466 | 60.9 kb | Distal (>10kb) Multiome | 155 | |
| chr8:81,912,367–81,913,089 | 69.9 kb | Distal (>10kb) Multiome | 113 |
Genomic view of the SNX16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.