This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. A similar protein in mouse may be involved in regulating the neurite outgrowth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for SNX12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNX12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNX12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:70,930,282–70,931,432 | 137.3 kb | Distal (>10kb) Multiome | 148 | |
| chrX:71,053,141–71,053,663 | 14.9 kb | Distal (>10kb) Multiome | 90 | |
| chrX:71,067,771–71,068,927 | 186 bp | At TSS Multiome | 846 | |
| chrX:71,095,671–71,096,651 | 27.6 kb | Distal (>10kb) Multiome | 450 | |
| chrX:71,103,137–71,103,903 | 35.2 kb | Distal (>10kb) Multiome | 375 | |
| chrX:71,181,957–71,182,785 | 113.9 kb | Distal (>10kb) Multiome | 615 | |
| chrX:71,253,749–71,255,053 | 185.9 kb | Distal (>10kb) Multiome | 607 | |
| chrX:71,283,100–71,284,134 | 215.2 kb | Distal (>10kb) Multiome | 633 | |
| chrX:71,365,705–71,366,636 | 297.8 kb | Distal (>10kb) Multiome | 578 |
Genomic view of the SNX12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.