This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function. This gene results in two transcript variants differing in the 5' UTR, but encoding the same protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SNX11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNX11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNX11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:47,831,256–47,831,955 | 276.0 kb | Distal (>10kb) Multiome | 856 | |
| chr17:47,840,790–47,841,702 | 266.3 kb | Distal (>10kb) Multiome | 833 | |
| chr17:47,847,253–47,848,429 | 259.9 kb | Distal (>10kb) Multiome | 193 | |
| chr17:47,850,617–47,851,614 | 256.4 kb | Distal (>10kb) Multiome | 694 | |
| chr17:47,895,361–47,896,955 | 211.5 kb | Distal (>10kb) Multiome | 1031 | |
| chr17:47,902,020–47,902,508 | 205.4 kb | Distal (>10kb) Multiome | 101 | |
| chr17:47,941,283–47,941,880 | 166.1 kb | Distal (>10kb) Multiome | 958 | |
| chr17:47,970,487–47,971,547 | 136.6 kb | Distal (>10kb) Multiome | 1061 | |
| chr17:48,023,351–48,024,470 | 84.0 kb | Distal (>10kb) Multiome | 591 | |
| chr17:48,024,599–48,025,777 | 82.3 kb | Distal (>10kb) Multiome | 759 | |
| chr17:48,026,284–48,026,933 | 80.9 kb | Distal (>10kb) Multiome | 543 | |
| chr17:48,047,576–48,049,198 | 59.3 kb | Distal (>10kb) Multiome | 1134 | |
| chr17:48,053,836–48,055,155 | 53.1 kb | Distal (>10kb) Multiome | 327 | |
| chr17:48,055,581–48,056,000 | 51.7 kb | Distal (>10kb) Multiome | 337 | |
| chr17:48,100,593–48,101,963 | 6.2 kb | Proximal (<10kb) Multiome | 974 | |
| chr17:48,107,198–48,108,007 | 22 bp | At TSS Multiome | 841 | |
| chr17:48,160,363–48,161,134 | 53.1 kb | Distal (>10kb) Multiome | 299 |
Genomic view of the SNX11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.