The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SNUPN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNUPN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNUPN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:75,335,855–75,336,339 | 289.7 kb | Distal (>10kb) Multiome | 665 | |
| chr15:75,346,877–75,348,733 | 278.3 kb | Distal (>10kb) Multiome | 738 | |
| chr15:75,367,625–75,369,002 | 257.6 kb | Distal (>10kb) Multiome HiCAR | 1121 | |
| chr15:75,450,273–75,456,388 | 169.8 kb | Distal (>10kb) Multiome | 1174 | |
| chr15:75,579,138–75,580,015 | 46.2 kb | Distal (>10kb) Multiome | 683 | |
| chr15:75,624,816–75,626,356 | 54 bp | At TSS Multiome | 987 | |
| chr15:75,639,562–75,640,798 | 14.6 kb | Distal (>10kb) Multiome | 999 | |
| chr15:75,647,017–75,648,674 | 22.2 kb | Distal (>10kb) Multiome | 795 | |
| chr15:75,672,794–75,673,400 | 47.3 kb | Distal (>10kb) Multiome | 226 | |
| chr15:75,712,716–75,713,248 | 87.2 kb | Distal (>10kb) Multiome | 318 | |
| chr15:75,738,177–75,739,332 | 113.0 kb | Distal (>10kb) Multiome | 611 | |
| chr15:75,758,383–75,758,865 | 132.9 kb | Distal (>10kb) Multiome | 550 | |
| chr15:75,823,901–75,824,543 | 198.4 kb | Distal (>10kb) Multiome | 98 | |
| chr15:75,842,738–75,844,503 | 217.5 kb | Distal (>10kb) Multiome | 842 | |
| chr15:75,903,363–75,904,635 | 278.2 kb | Distal (>10kb) Multiome | 958 |
Genomic view of the SNUPN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.