Transcription factors with Perturb-seq knockdown data for SNTG2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNTG2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNTG2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:676,032–677,904 | 273.7 kb | Distal (>10kb) Multiome | 1125 | |
| chr2:739,661–741,352 | 210.1 kb | Distal (>10kb) Multiome | 302 | |
| chr2:949,713–951,620 | 20 bp | At TSS Multiome | 318 | |
| chr2:951,724–951,992 | 970 bp | At TSS | 63 |
Genomic view of the SNTG2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.