The protein encoded by this gene is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role in the 3' end processing of histone transcripts. This protein is one of the targets in the autoimmune disease systemic lupus erythematosus, and mutations in this gene have been associated with hypotrichosis. Several pseudogenes of this gene have been identified. [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for SNRPE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNRPE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNRPE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:203,585,330–203,586,179 | 275.9 kb | Distal (>10kb) Multiome | 85 | |
| chr1:203,592,048–203,592,904 | 269.1 kb | Distal (>10kb) Multiome | 170 | |
| chr1:203,626,216–203,627,194 | 234.8 kb | Distal (>10kb) Multiome | 626 | |
| chr1:203,627,926–203,630,057 | 233.0 kb | Distal (>10kb) Multiome | 425 | |
| chr1:203,650,175–203,650,835 | 211.1 kb | Distal (>10kb) Multiome | 596 | |
| chr1:203,795,422–203,796,461 | 65.9 kb | Distal (>10kb) Multiome | 784 | |
| chr1:203,861,102–203,862,191 | 42 bp | At TSS Multiome | 1090 | |
| chr1:203,871,163–203,871,356 | 9.6 kb | Proximal (<10kb) | 181 | |
| chr1:203,996,153–203,997,412 | 135.3 kb | Distal (>10kb) Multiome | 210 | |
| chr1:204,065,124–204,065,934 | 203.9 kb | Distal (>10kb) Multiome HiCAR | 155 | |
| chr1:204,072,301–204,075,400 | 211.5 kb | Distal (>10kb) Multiome HiCAR | 828 | |
| chr1:204,078,065–204,078,999 | 216.9 kb | Distal (>10kb) Multiome HiCAR | 348 | |
| chr1:204,079,587–204,080,941 | 219.0 kb | Distal (>10kb) Multiome HiCAR | 492 | |
| chr1:204,084,225–204,084,936 | 223.0 kb | Distal (>10kb) Multiome HiCAR | 439 | |
| chr1:204,108,483–204,109,315 | 247.3 kb | Distal (>10kb) Multiome HiCAR | 151 | |
| chr1:204,128,928–204,129,568 | 267.7 kb | Distal (>10kb) Multiome HiCAR | 440 | |
| chr1:204,151,279–204,152,703 | 290.5 kb | Distal (>10kb) Multiome HiCAR | 556 | |
| chr1:204,213,764–204,214,668 | 352.6 kb | Distal (>10kb) Multiome HiCAR | 702 | |
| chr1:204,350,954–204,351,460 | 489.6 kb | Distal (>10kb) Multiome HiCAR | 138 |
Genomic view of the SNRPE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.