Enables RNA binding activity. Involved in mRNA splicing, via spliceosome and spermatogenesis. Located in nuclear speck. Part of U2-type catalytic step 2 spliceosome and U2-type precatalytic spliceosome. Implicated in connective tissue disease. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SNRPA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNRPA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNRPA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:101,008,268–101,008,757 | 286.6 kb | Distal (>10kb) Multiome | 571 | |
| chr15:101,068,707–101,069,646 | 225.9 kb | Distal (>10kb) Multiome | 435 | |
| chr15:101,077,927–101,078,550 | 217.1 kb | Distal (>10kb) Multiome | 35 | |
| chr15:101,088,678–101,089,262 | 206.2 kb | Distal (>10kb) Multiome | 541 | |
| chr15:101,201,405–101,201,942 | 93.6 kb | Distal (>10kb) Multiome | 276 | |
| chr15:101,250,886–101,252,530 | 43.2 kb | Distal (>10kb) Multiome | 729 | |
| chr15:101,276,817–101,277,913 | 17.7 kb | Distal (>10kb) Multiome | 748 | |
| chr15:101,294,732–101,295,714 | 67 bp | At TSS Multiome | 987 | |
| chr15:101,489,250–101,490,332 | 194.4 kb | Distal (>10kb) Multiome | 422 | |
| chr15:101,615,676–101,616,370 | 320.9 kb | Distal (>10kb) Multiome HiCAR | 506 | |
| chr15:101,651,697–101,653,159 | 357.2 kb | Distal (>10kb) Multiome HiCAR | 1015 |
Genomic view of the SNRPA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.