The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]
Transcription factors with Perturb-seq knockdown data for SNRPA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNRPA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNRPA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:40,465,326–40,466,635 | 285.0 kb | Distal (>10kb) Multiome | 815 | |
| chr19:40,487,850–40,488,306 | 262.8 kb | Distal (>10kb) Multiome | 193 | |
| chr19:40,519,457–40,519,993 | 231.2 kb | Distal (>10kb) Multiome | 222 | |
| chr19:40,528,978–40,529,879 | 221.6 kb | Distal (>10kb) Multiome | 601 | |
| chr19:40,529,987–40,530,863 | 220.2 kb | Distal (>10kb) Multiome | 384 | |
| chr19:40,549,036–40,549,555 | 201.5 kb | Distal (>10kb) Multiome | 372 | |
| chr19:40,570,181–40,571,253 | 180.1 kb | Distal (>10kb) Multiome | 598 | |
| chr19:40,576,133–40,577,495 | 174.0 kb | Distal (>10kb) Multiome | 616 | |
| chr19:40,596,828–40,597,429 | 153.8 kb | Distal (>10kb) Multiome | 354 | |
| chr19:40,598,094–40,598,871 | 152.3 kb | Distal (>10kb) Multiome | 606 | |
| chr19:40,603,345–40,604,624 | 146.8 kb | Distal (>10kb) Multiome | 889 | |
| chr19:40,604,983–40,606,597 | 145.1 kb | Distal (>10kb) Multiome | 708 | |
| chr19:40,609,543–40,610,691 | 140.8 kb | Distal (>10kb) Multiome | 519 | |
| chr19:40,612,884–40,615,179 | 137.2 kb | Distal (>10kb) Multiome | 595 | |
| chr19:40,623,557–40,624,516 | 126.8 kb | Distal (>10kb) Multiome | 454 | |
| chr19:40,634,333–40,634,959 | 116.3 kb | Distal (>10kb) Multiome | 629 | |
| chr19:40,662,838–40,663,654 | 87.8 kb | Distal (>10kb) Multiome | 856 | |
| chr19:40,689,888–40,691,759 | 60.1 kb | Distal (>10kb) Multiome | 691 | |
| chr19:40,714,822–40,715,454 | 35.7 kb | Distal (>10kb) Multiome | 531 | |
| chr19:40,716,605–40,717,875 | 33.8 kb | Distal (>10kb) Multiome | 772 | |
| chr19:40,750,206–40,751,874 | 50 bp | At TSS Multiome | 989 | |
| chr19:40,777,237–40,779,173 | 27.4 kb | Distal (>10kb) Multiome | 901 | |
| chr19:40,798,002–40,799,843 | 48.1 kb | Distal (>10kb) Multiome | 936 | |
| chr19:40,806,580–40,807,205 | 56.1 kb | Distal (>10kb) Multiome | 496 | |
| chr19:40,810,733–40,811,261 | 60.1 kb | Distal (>10kb) Multiome | 115 |
Genomic view of the SNRPA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.