This gene encodes a serine/arginine-rich (SR) protein. SR proteins play important roles in pre-mRNA splicing by facilitating the recognition and selection of splice sites. The encoded protein associates with the 25S U4/U6.U5 tri-snRNP, a major component of the U2-type spiceosome. The expression of this gene may be altered in cells infected with the human T-cell lymphotropic virus type 1 (HTLV-1) retrovirus. A pseudogene of this gene is located on the long arm of chromosome 5. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for SNRNP27. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNRNP27 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNRNP27, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:69,642,875–69,644,362 | 250.1 kb | Distal (>10kb) Multiome | 960 | |
| chr2:69,741,315–69,742,479 | 152.0 kb | Distal (>10kb) Multiome | 894 | |
| chr2:69,798,793–69,799,774 | 94.7 kb | Distal (>10kb) Multiome | 417 | |
| chr2:69,829,001–69,830,537 | 64.4 kb | Distal (>10kb) Multiome | 1005 | |
| chr2:69,893,834–69,894,224 | at TSS | At TSS | 896 | |
| chr2:69,914,102–69,915,874 | 20.9 kb | Distal (>10kb) Multiome | 1112 | |
| chr2:70,084,998–70,085,484 | 191.3 kb | Distal (>10kb) Multiome HiCAR | 345 | |
| chr2:70,086,194–70,088,572 | 193.1 kb | Distal (>10kb) Multiome HiCAR | 1204 | |
| chr2:70,089,216–70,090,447 | 195.8 kb | Distal (>10kb) Multiome HiCAR | 459 | |
| chr2:70,123,128–70,125,445 | 229.6 kb | Distal (>10kb) Multiome | 779 | |
| chr2:70,140,819–70,143,188 | 248.7 kb | Distal (>10kb) Multiome HiCAR | 1260 | |
| chr2:70,190,215–70,191,415 | 297.0 kb | Distal (>10kb) Multiome | 1013 |
Genomic view of the SNRNP27 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.