Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 25K protein that is a component of the U12-type spliceosome. [provided by RefSeq, Apr 2010]
Transcription factors with Perturb-seq knockdown data for SNRNP25. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNRNP25 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNRNP25, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:52,954–54,208 | 161 bp | At TSS Multiome | 950 | |
| chr16:71,378–73,062 | 17.6 kb | Distal (>10kb) Multiome | 639 | |
| chr16:77,240–78,636 | 24.3 kb | Distal (>10kb) Multiome | 685 | |
| chr16:138,551–139,186 | 84.8 kb | Distal (>10kb) Multiome | 674 | |
| chr16:164,983–166,147 | 111.2 kb | Distal (>10kb) Multiome | 234 | |
| chr16:180,313–181,713 | 127.6 kb | Distal (>10kb) Multiome | 994 | |
| chr16:228,869–229,598 | 175.4 kb | Distal (>10kb) Multiome | 1035 | |
| chr16:234,152–235,669 | 180.9 kb | Distal (>10kb) Multiome | 908 | |
| chr16:351,804–354,436 | 299.1 kb | Distal (>10kb) Multiome | 654 |
Genomic view of the SNRNP25 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.