Enables metal ion binding activity. Predicted to be involved in response to toxic substance. Located in cytoplasm and membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SNN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:11,586,675–11,587,433 | 81.3 kb | Distal (>10kb) Multiome | 663 | |
| chr16:11,667,937–11,668,794 | 56 bp | At TSS Multiome | 540 | |
| chr16:11,742,120–11,743,349 | 74.4 kb | Distal (>10kb) Multiome | 1040 | |
| chr16:11,796,876–11,797,981 | 128.9 kb | Distal (>10kb) Multiome | 986 | |
| chr16:11,851,115–11,852,070 | 183.1 kb | Distal (>10kb) Multiome | 978 | |
| chr16:11,876,086–11,876,741 | 207.9 kb | Distal (>10kb) Multiome | 80 | |
| chr16:11,915,000–11,916,719 | 247.6 kb | Distal (>10kb) Multiome | 1130 |
Genomic view of the SNN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.