This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for SNIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:37,473,950–37,475,117 | 79.8 kb | Distal (>10kb) Multiome | 695 | |
| chr1:37,513,871–37,515,291 | 39.5 kb | Distal (>10kb) Multiome | 884 | |
| chr1:37,553,845–37,554,497 | 3 bp | At TSS Multiome | 748 | |
| chr1:37,556,626–37,557,247 | 2.6 kb | Proximal (<10kb) Multiome | 284 | |
| chr1:37,595,631–37,596,377 | 41.7 kb | Distal (>10kb) Multiome | 754 | |
| chr1:37,634,598–37,635,064 | 80.5 kb | Distal (>10kb) Multiome | 192 | |
| chr1:37,663,328–37,663,865 | 109.3 kb | Distal (>10kb) Multiome | 44 | |
| chr1:37,690,078–37,690,919 | 136.3 kb | Distal (>10kb) Multiome | 679 | |
| chr1:37,691,459–37,692,843 | 138.1 kb | Distal (>10kb) Multiome | 781 | |
| chr1:37,752,766–37,753,277 | 198.8 kb | Distal (>10kb) Multiome | 223 | |
| chr1:37,793,768–37,794,528 | 239.8 kb | Distal (>10kb) Multiome | 567 | |
| chr1:37,807,583–37,809,057 | 253.9 kb | Distal (>10kb) Multiome | 755 |
Genomic view of the SNIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.