This gene represent a snoRNA host gene and produces a long non-coding RNA. This RNA may regulate gene expression by acting as a sponge for microRNAs. This transcript may also stabilize mRNAs by blocking degradation by staufen double-stranded RNA binding protein 1. [provided by RefSeq, Dec 2017]
Transcription factors with Perturb-seq knockdown data for SNHG5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNHG5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNHG5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:85,449,270–85,450,999 | 228.7 kb | Distal (>10kb) Multiome | 777 | |
| chr6:85,592,894–85,594,816 | 84.8 kb | Distal (>10kb) Multiome | 1023 | |
| chr6:85,641,813–85,644,323 | 35.2 kb | Distal (>10kb) Multiome | 1160 | |
| chr6:85,644,944–85,645,801 | 33.4 kb | Distal (>10kb) Multiome HiCAR | 220 | |
| chr6:85,669,340–85,674,412 | 8.7 kb | Proximal (<10kb) Multiome | 586 | |
| chr6:85,674,652–85,675,780 | 3.0 kb | Proximal (<10kb) | 256 | |
| chr6:85,677,372–85,679,519 | 153 bp | At TSS Multiome | 1177 | |
| chr6:85,899,026–85,900,144 | 220.8 kb | Distal (>10kb) Multiome | 210 | |
| chr6:86,943,714–86,944,451 | 1265.4 kb | Distal (>10kb) Multiome HiCAR | 102 |
Genomic view of the SNHG5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.