This gene produces a long RNA that is overexpressed in tumor cells. This RNA may promote tumorigenesis by acting as a sponge for microRNAs. [provided by RefSeq, Dec 2017]
Transcription factors with Perturb-seq knockdown data for SNHG12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNHG12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNHG12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:28,369,387–28,370,499 | 212.1 kb | Distal (>10kb) Multiome | 961 | |
| chr1:28,505,412–28,506,885 | 75.9 kb | Distal (>10kb) Multiome | 969 | |
| chr1:28,513,136–28,516,505 | 66.4 kb | Distal (>10kb) Multiome | 461 | |
| chr1:28,517,302–28,519,364 | 63.5 kb | Distal (>10kb) Multiome | 927 | |
| chr1:28,552,370–28,553,806 | 28.9 kb | Distal (>10kb) Multiome | 955 | |
| chr1:28,580,985–28,582,501 | 17 bp | At TSS Multiome | 1080 | |
| chr1:28,582,603–28,583,287 | 725 bp | At TSS | 171 | |
| chr1:28,592,018–28,592,768 | 10.5 kb | Distal (>10kb) Multiome | 394 | |
| chr1:28,642,403–28,643,726 | 61.3 kb | Distal (>10kb) Multiome | 980 | |
| chr1:28,648,003–28,650,002 | 67.0 kb | Distal (>10kb) Multiome | 1377 | |
| chr1:28,667,742–28,669,783 | 86.5 kb | Distal (>10kb) Multiome | 804 | |
| chr1:28,736,098–28,738,080 | 154.8 kb | Distal (>10kb) Multiome | 1106 | |
| chr1:28,811,880–28,812,661 | 230.4 kb | Distal (>10kb) Multiome | 219 | |
| chr1:28,881,894–28,882,433 | 300.4 kb | Distal (>10kb) Multiome | 615 |
Genomic view of the SNHG12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.