The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins to the lysosome for degradation. This complex also interacts with the RNA polymerase II elongation factor (ELL) to overcome the repressive effects of ELL on RNA polymerase II activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for SNF8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNF8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNF8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:48,671,728–48,672,690 | 272.3 kb | Distal (>10kb) Multiome | 409 | |
| chr17:48,678,104–48,678,743 | 266.3 kb | Distal (>10kb) Multiome | 453 | |
| chr17:48,718,468–48,719,563 | 225.9 kb | Distal (>10kb) Multiome | 164 | |
| chr17:48,719,708–48,720,337 | 224.8 kb | Distal (>10kb) Multiome | 181 | |
| chr17:48,722,219–48,723,762 | 221.9 kb | Distal (>10kb) Multiome | 220 | |
| chr17:48,728,286–48,729,570 | 215.9 kb | Distal (>10kb) Multiome | 376 | |
| chr17:48,816,754–48,817,592 | 127.6 kb | Distal (>10kb) Multiome | 589 | |
| chr17:48,830,670–48,831,519 | 113.8 kb | Distal (>10kb) Multiome | 838 | |
| chr17:48,891,910–48,893,540 | 52.2 kb | Distal (>10kb) Multiome | 1059 | |
| chr17:48,907,825–48,909,317 | 36.5 kb | Distal (>10kb) Multiome | 1011 | |
| chr17:48,944,483–48,945,203 | 36 bp | At TSS Multiome | 1009 | |
| chr17:48,995,124–48,997,874 | 52.6 kb | Distal (>10kb) Multiome | 1057 | |
| chr17:49,013,253–49,014,714 | 69.2 kb | Distal (>10kb) Multiome | 480 | |
| chr17:49,022,149–49,022,993 | 77.8 kb | Distal (>10kb) Multiome | 306 | |
| chr17:49,031,811–49,032,444 | 87.5 kb | Distal (>10kb) Multiome HiCAR | 423 | |
| chr17:49,035,641–49,036,299 | 91.2 kb | Distal (>10kb) Multiome HiCAR | 338 | |
| chr17:49,191,794–49,193,465 | 248.0 kb | Distal (>10kb) Multiome | 1177 | |
| chr17:49,223,535–49,224,633 | 278.9 kb | Distal (>10kb) Multiome | 281 | |
| chr17:49,230,380–49,231,209 | 286.1 kb | Distal (>10kb) Multiome | 496 |
Genomic view of the SNF8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.