This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and mediate synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While the protein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SNAP29. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNAP29 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNAP29, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:20,606,015–20,606,540 | 252.6 kb | Distal (>10kb) Multiome | 411 | |
| chr22:20,702,218–20,703,674 | 156.0 kb | Distal (>10kb) Multiome | 438 | |
| chr22:20,857,959–20,859,512 | 238 bp | At TSS Multiome | 901 | |
| chr22:20,885,370–20,886,088 | 26.8 kb | Distal (>10kb) Multiome | 749 | |
| chr22:20,916,779–20,918,119 | 58.2 kb | Distal (>10kb) Multiome | 985 | |
| chr22:20,957,739–20,958,321 | 98.8 kb | Distal (>10kb) Multiome | 346 | |
| chr22:20,979,087–20,980,257 | 120.5 kb | Distal (>10kb) Multiome | 435 | |
| chr22:20,981,807–20,982,763 | 123.1 kb | Distal (>10kb) Multiome | 1020 | |
| chr22:21,001,335–21,002,797 | 143.0 kb | Distal (>10kb) Multiome | 1021 | |
| chr22:21,013,880–21,015,021 | 155.3 kb | Distal (>10kb) Multiome | 661 | |
| chr22:21,045,516–21,046,316 | 186.8 kb | Distal (>10kb) Multiome | 414 |
Genomic view of the SNAP29 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.