Enables protein-lysine N-methyltransferase activity. Involved in positive regulation of cytoplasmic translational elongation; regulation of stem cell differentiation; and transposable element silencing by heterochromatin formation. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SMYD5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMYD5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMYD5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:72,915,937–72,919,139 | 296.7 kb | Distal (>10kb) Multiome | 786 | |
| chr2:72,919,971–72,921,133 | 293.7 kb | Distal (>10kb) Multiome | 150 | |
| chr2:72,924,149–72,925,197 | 289.8 kb | Distal (>10kb) Multiome | 169 | |
| chr2:72,951,372–72,951,860 | 262.7 kb | Distal (>10kb) Multiome | 115 | |
| chr2:72,963,185–72,963,825 | 250.7 kb | Distal (>10kb) Multiome | 135 | |
| chr2:73,070,503–73,072,300 | 142.7 kb | Distal (>10kb) Multiome | 1016 | |
| chr2:73,111,353–73,113,710 | 101.1 kb | Distal (>10kb) Multiome | 903 | |
| chr2:73,156,488–73,157,075 | 57.5 kb | Distal (>10kb) Multiome | 419 | |
| chr2:73,175,306–73,176,433 | 38.5 kb | Distal (>10kb) Multiome | 499 | |
| chr2:73,176,845–73,177,711 | 36.7 kb | Distal (>10kb) Multiome | 779 | |
| chr2:73,202,161–73,203,581 | 11.7 kb | Distal (>10kb) Multiome | 227 | |
| chr2:73,212,561–73,212,799 | 1.4 kb | Proximal (<10kb) | 383 | |
| chr2:73,214,088–73,214,797 | 117 bp | At TSS Multiome | 870 | |
| chr2:73,232,770–73,234,882 | 20.3 kb | Distal (>10kb) Multiome | 1129 | |
| chr2:73,268,616–73,269,882 | 54.9 kb | Distal (>10kb) Multiome | 384 | |
| chr2:73,283,511–73,285,190 | 70.3 kb | Distal (>10kb) Multiome | 734 | |
| chr2:73,291,197–73,292,186 | 77.3 kb | Distal (>10kb) Multiome | 609 | |
| chr2:73,293,075–73,294,022 | 79.5 kb | Distal (>10kb) Multiome | 382 | |
| chr2:73,385,262–73,386,724 | 171.7 kb | Distal (>10kb) Multiome | 893 |
Genomic view of the SMYD5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.