Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SMIM7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMIM7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMIM7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:16,471,332–16,472,638 | 188.1 kb | Distal (>10kb) Multiome | 645 | |
| chr19:16,495,870–16,496,694 | 163.9 kb | Distal (>10kb) Multiome | 780 | |
| chr19:16,541,995–16,543,080 | 117.6 kb | Distal (>10kb) Multiome | 880 | |
| chr19:16,571,833–16,572,764 | 87.6 kb | Distal (>10kb) Multiome | 814 | |
| chr19:16,627,176–16,629,209 | 31.8 kb | Distal (>10kb) Multiome | 896 | |
| chr19:16,659,555–16,661,823 | 25 bp | At TSS Multiome | 987 | |
| chr19:16,828,911–16,830,011 | 169.2 kb | Distal (>10kb) Multiome | 623 | |
| chr19:16,895,945–16,898,066 | 237.1 kb | Distal (>10kb) Multiome | 632 |
Genomic view of the SMIM7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.