Enables protein kinase binding activity and transmembrane transporter binding activity. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SMIM26. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMIM26 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMIM26, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:18,287,674–18,288,982 | 279.1 kb | Distal (>10kb) Multiome | 971 | |
| chr20:18,413,071–18,413,534 | 154.1 kb | Distal (>10kb) Multiome | 167 | |
| chr20:18,466,666–18,467,699 | 100.3 kb | Distal (>10kb) Multiome | 930 | |
| chr20:18,496,758–18,497,430 | 70.2 kb | Distal (>10kb) Multiome | 820 | |
| chr20:18,507,260–18,508,352 | 59.7 kb | Distal (>10kb) Multiome | 959 | |
| chr20:18,566,948–18,567,920 | 54 bp | At TSS Multiome | 957 | |
| chr20:18,587,564–18,588,839 | 20.6 kb | Distal (>10kb) Multiome | 882 | |
| chr20:18,793,728–18,794,660 | 226.7 kb | Distal (>10kb) Multiome | 767 |
Genomic view of the SMIM26 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.