Transcription factors with Perturb-seq knockdown data for SMIM15-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMIM15-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMIM15-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:60,944,760–60,946,207 | 217.3 kb | Distal (>10kb) Multiome | 759 | |
| chr5:61,161,875–61,163,757 | 17 bp | At TSS Multiome | 985 | |
| chr5:61,168,830–61,169,511 | 6.7 kb | Proximal (<10kb) Multiome | 120 | |
| chr5:61,289,226–61,290,050 | 127.0 kb | Distal (>10kb) Multiome | 194 | |
| chr5:61,308,730–61,309,558 | 146.7 kb | Distal (>10kb) Multiome HiCAR | 77 | |
| chr5:61,310,974–61,311,527 | 148.7 kb | Distal (>10kb) Multiome HiCAR | 145 | |
| chr5:61,330,246–61,334,009 | 169.5 kb | Distal (>10kb) Multiome | 953 | |
| chr5:61,408,527–61,409,188 | 246.4 kb | Distal (>10kb) Multiome | 781 | |
| chr5:61,625,646–61,626,958 | 463.6 kb | Distal (>10kb) Multiome HiCAR | 354 |
Genomic view of the SMIM15-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.