Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SMIM11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMIM11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMIM11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:33,491,033–33,492,145 | 883.9 kb | Distal (>10kb) Multiome HiCAR | 740 | |
| chr21:33,894,789–33,895,286 | 480.6 kb | Distal (>10kb) Multiome HiCAR | 371 | |
| chr21:33,915,370–33,916,223 | 459.7 kb | Distal (>10kb) Multiome HiCAR | 730 | |
| chr21:34,072,589–34,075,396 | 300.6 kb | Distal (>10kb) Multiome HiCAR | 822 | |
| chr21:34,201,488–34,202,922 | 173.5 kb | Distal (>10kb) Multiome | 669 | |
| chr21:34,614,583–34,615,668 | 239.7 kb | Distal (>10kb) Multiome HiCAR | 722 | |
| chr21:34,865,900–34,866,326 | 490.5 kb | Distal (>10kb) Multiome HiCAR | 314 | |
| chr21:36,155,542–36,157,554 | 1781.0 kb | Distal (>10kb) Multiome HiCAR | 789 |
Genomic view of the SMIM11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.