SMDT1

single-pass membrane protein with aspartate rich tail 1 | DDDD, EMRE, dJ186O1.1, C22orf32

This gene encodes a core regulatory component of a calcium channel in the mitochondrial inner membrane. [provided by RefSeq, Apr 2017]

Member of: DE-1

Biological processes 26 terms

calcium import into the mitochondrion (GO:0036444)calcium import into the mitochondrion (GO:0036444)calcium import into the mitochondrion (GO:0036444)calcium import into the mitochondrion (GO:0036444)calcium import into the mitochondrion (GO:0036444)cellular response to calcium ion starvation (GO:0072732)channel activator activity (GO:0099103)mitochondrial calcium ion homeostasis (GO:0051560)mitochondrial calcium ion homeostasis (GO:0051560)mitochondrial calcium ion homeostasis (GO:0051560)mitochondrial calcium ion homeostasis (GO:0051560)mitochondrial calcium ion homeostasis (GO:0051560)mitochondrial calcium ion transmembrane transport (GO:0006851)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial matrix (GO:0005759)mitochondrion (GO:0005739)mitochondrion (GO:0005739)protein binding (GO:0005515)protein-macromolecule adaptor activity (GO:0030674)uniplex complex (GO:1990246)uniplex complex (GO:1990246)uniplex complex (GO:1990246)

Expression (TPM)

TFs regulating SMDT1 0 TFs

Transcription factors with Perturb-seq knockdown data for SMDT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMDT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SMDT1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMDT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr22:41,800,274–41,801,345	279.1 kb	Distal (>10kb) Multiome	816
chr22:41,832,291–41,834,215	246.8 kb	Distal (>10kb) Multiome	1023
chr22:41,845,927–41,846,489	233.6 kb	Distal (>10kb) Multiome	271
chr22:41,909,821–41,910,788	169.4 kb	Distal (>10kb) Multiome	251
chr22:41,913,915–41,914,497	165.5 kb	Distal (>10kb) Multiome	143
chr22:41,914,624–41,915,454	164.6 kb	Distal (>10kb) Multiome	273
chr22:41,919,501–41,920,436	159.7 kb	Distal (>10kb) Multiome	337
chr22:41,926,076–41,926,820	153.4 kb	Distal (>10kb) Multiome	442
chr22:41,945,821–41,947,304	132.8 kb	Distal (>10kb) Multiome	896
chr22:41,957,553–41,958,332	121.8 kb	Distal (>10kb) Multiome	456
chr22:41,976,503–41,977,084	102.9 kb	Distal (>10kb) Multiome	294
chr22:42,070,303–42,071,253	8.9 kb	Proximal (<10kb) Multiome	833
chr22:42,074,171–42,074,703	5.3 kb	Proximal (<10kb) Multiome	178
chr22:42,079,194–42,080,293	78 bp	At TSS Multiome	872
chr22:42,080,429–42,080,566	730 bp	At TSS	123
chr22:42,090,032–42,091,609	11.2 kb	Distal (>10kb) Multiome	910
chr22:42,269,385–42,271,172	191.0 kb	Distal (>10kb) Multiome	751
chr22:42,343,251–42,344,201	263.9 kb	Distal (>10kb) Multiome	220
chr22:42,344,438–42,344,933	265.1 kb	Distal (>10kb) Multiome	162
chr22:42,365,301–42,366,142	285.9 kb	Distal (>10kb) Multiome	197
chr22:42,368,263–42,369,908	289.6 kb	Distal (>10kb) Multiome	592
chr22:42,499,840–42,501,072	420.7 kb	Distal (>10kb) Multiome HiCAR	356

Genome Browser

Genomic view of the SMDT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.