The protein encoded by this gene is similar to the mouse stromal membrane-associated protein-1. This similarity suggests that this human gene product is also a type II membrane glycoprotein involved in the erythropoietic stimulatory activity of stromal cells. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SMAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:70,412,616–70,414,468 | 254.5 kb | Distal (>10kb) Multiome | 868 | |
| chr6:70,566,096–70,567,415 | 101.0 kb | Distal (>10kb) Multiome | 830 | |
| chr6:70,667,079–70,668,698 | 7 bp | At TSS Multiome | 889 | |
| chr6:70,673,739–70,673,919 | 6.0 kb | Proximal (<10kb) | 50 | |
| chr6:70,674,682–70,675,166 | 6.9 kb | Proximal (<10kb) | 5 | |
| chr6:70,675,541–70,676,084 | 7.8 kb | Proximal (<10kb) | 17 | |
| chr6:70,884,016–70,885,914 | 216.6 kb | Distal (>10kb) Multiome | 366 | |
| chr6:70,954,815–70,957,638 | 288.0 kb | Distal (>10kb) Multiome | 768 |
Genomic view of the SMAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.