Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SLU7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLU7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLU7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:160,118,295–160,120,363 | 299.4 kb | Distal (>10kb) Multiome | 890 | |
| chr5:160,133,074–160,134,351 | 285.5 kb | Distal (>10kb) Multiome | 270 | |
| chr5:160,159,956–160,160,873 | 258.8 kb | Distal (>10kb) Multiome | 276 | |
| chr5:160,161,037–160,162,516 | 257.2 kb | Distal (>10kb) Multiome | 167 | |
| chr5:160,165,122–160,166,166 | 253.2 kb | Distal (>10kb) Multiome | 537 | |
| chr5:160,188,095–160,189,161 | 230.5 kb | Distal (>10kb) Multiome | 472 | |
| chr5:160,199,034–160,200,016 | 219.5 kb | Distal (>10kb) Multiome | 455 | |
| chr5:160,287,012–160,288,061 | 131.4 kb | Distal (>10kb) Multiome | 461 | |
| chr5:160,311,564–160,313,046 | 106.5 kb | Distal (>10kb) Multiome | 576 | |
| chr5:160,344,991–160,345,682 | 73.7 kb | Distal (>10kb) Multiome | 420 | |
| chr5:160,399,366–160,400,211 | 19.2 kb | Distal (>10kb) Multiome | 808 | |
| chr5:160,416,486–160,416,678 | 2.4 kb | Proximal (<10kb) | 9 | |
| chr5:160,418,768–160,419,557 | 71 bp | At TSS Multiome | 703 | |
| chr5:160,421,652–160,422,209 | 2.8 kb | Proximal (<10kb) Multiome | 576 | |
| chr5:160,423,244–160,423,455 | 4.2 kb | Proximal (<10kb) | 66 | |
| chr5:160,423,607–160,423,772 | 4.5 kb | Proximal (<10kb) | 16 | |
| chr5:160,438,451–160,439,591 | 20.1 kb | Distal (>10kb) Multiome | 556 |
Genomic view of the SLU7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.