Enables RNA binding activity. Predicted to be involved in regulation of mRNA processing and regulation of transcription by RNA polymerase II. Located in nuclear body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLTM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLTM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLTM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:58,748,777–58,750,495 | 183.8 kb | Distal (>10kb) Multiome | 819 | |
| chr15:58,770,593–58,772,279 | 162.5 kb | Distal (>10kb) Multiome | 996 | |
| chr15:58,833,690–58,834,207 | 99.7 kb | Distal (>10kb) Multiome | 126 | |
| chr15:58,864,709–58,865,675 | 68.6 kb | Distal (>10kb) Multiome | 533 | |
| chr15:58,932,998–58,934,288 | 8 bp | At TSS Multiome | 943 | |
| chr15:58,987,470–58,988,521 | 54.2 kb | Distal (>10kb) Multiome | 812 | |
| chr15:59,104,922–59,105,729 | 171.5 kb | Distal (>10kb) Multiome | 716 |
Genomic view of the SLTM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.