SLIT1

slit guidance ligand 1 | MEGF4, SLIT3, Slit-1, SLIL1

Enables Roundabout binding activity. Involved in axon extension involved in axon guidance; motor neuron axon guidance; and negative chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 25 terms

Roundabout binding (GO:0048495)Roundabout binding (GO:0048495)Roundabout binding (GO:0048495)axon extension involved in axon guidance (GO:0048846)axon extension involved in axon guidance (GO:0048846)axon guidance (GO:0007411)axon guidance (GO:0007411)calcium ion binding (GO:0005509)calcium ion binding (GO:0005509)chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration (GO:0021834)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)forebrain morphogenesis (GO:0048853)heparan sulfate proteoglycan binding (GO:0043395)heparin binding (GO:0008201)motor neuron axon guidance (GO:0008045)motor neuron axon guidance (GO:0008045)negative chemotaxis (GO:0050919)negative chemotaxis (GO:0050919)negative chemotaxis (GO:0050919)negative regulation of axon extension involved in axon guidance (GO:0048843)negative regulation of synapse assembly (GO:0051964)protein binding (GO:0005515)spinal cord development (GO:0021510)

Expression (TPM)

TFs regulating SLIT1 0 TFs

Transcription factors with Perturb-seq knockdown data for SLIT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLIT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SLIT1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLIT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr10:97,037,342–97,037,879	148.3 kb	Distal (>10kb) Multiome	469
chr10:97,179,559–97,180,186	5.8 kb	Proximal (<10kb) Multiome	190
chr10:97,185,462–97,186,037	80 bp	At TSS Multiome	248
chr10:97,195,967–97,196,850	10.7 kb	Distal (>10kb) Multiome	469
chr10:97,291,972–97,293,103	106.8 kb	Distal (>10kb) Multiome	945
chr10:97,318,840–97,320,386	133.3 kb	Distal (>10kb) Multiome	836
chr10:97,333,472–97,335,742	149.1 kb	Distal (>10kb) Multiome	917
chr10:97,336,929–97,337,706	151.5 kb	Distal (>10kb) Multiome	362
chr10:97,400,817–97,401,691	215.5 kb	Distal (>10kb) Multiome	644
chr10:97,407,246–97,407,739	221.6 kb	Distal (>10kb) Multiome	539
chr10:97,418,830–97,419,461	233.3 kb	Distal (>10kb) Multiome	323
chr10:97,425,050–97,426,796	240.3 kb	Distal (>10kb) Multiome	715
chr10:97,445,521–97,446,585	260.3 kb	Distal (>10kb) Multiome	802

Genome Browser

Genomic view of the SLIT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.