Enables ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Located in nucleoplasm and site of double-strand break. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:94,354,742–94,355,553 | 263.5 kb | Distal (>10kb) Multiome | 109 | |
| chr5:94,361,832–94,363,141 | 256.2 kb | Distal (>10kb) Multiome | 249 | |
| chr5:94,573,261–94,574,252 | 45.1 kb | Distal (>10kb) Multiome | 127 | |
| chr5:94,613,666–94,613,853 | 4.8 kb | Proximal (<10kb) | 72 | |
| chr5:94,617,832–94,619,385 | 12 bp | At TSS Multiome | 878 | |
| chr5:94,724,538–94,725,707 | 106.5 kb | Distal (>10kb) Multiome | 128 |
Genomic view of the SLF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.