Enables organic anion transmembrane transporter activity and prostaglandin transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be active in basolateral plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLCO4A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLCO4A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLCO4A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:62,365,805–62,369,404 | 273.6 kb | Distal (>10kb) Multiome | 960 | |
| chr20:62,386,553–62,387,309 | 255.5 kb | Distal (>10kb) Multiome | 885 | |
| chr20:62,406,793–62,407,817 | 235.1 kb | Distal (>10kb) Multiome | 935 | |
| chr20:62,475,060–62,476,807 | 166.5 kb | Distal (>10kb) Multiome | 378 | |
| chr20:62,641,913–62,643,114 | 119 bp | At TSS Multiome | 874 | |
| chr20:62,793,003–62,795,717 | 151.9 kb | Distal (>10kb) Multiome | 1051 | |
| chr20:62,796,248–62,797,075 | 154.0 kb | Distal (>10kb) Multiome | 566 | |
| chr20:62,815,479–62,817,462 | 173.4 kb | Distal (>10kb) Multiome | 503 | |
| chr20:62,860,497–62,862,892 | 219.4 kb | Distal (>10kb) Multiome | 996 | |
| chr20:62,900,083–62,900,558 | 257.9 kb | Distal (>10kb) Multiome | 764 | |
| chr20:62,925,950–62,926,856 | 284.1 kb | Distal (>10kb) Multiome | 874 | |
| chr20:62,928,980–62,929,573 | 286.8 kb | Distal (>10kb) Multiome | 289 | |
| chr20:62,937,285–62,938,569 | 295.5 kb | Distal (>10kb) Multiome | 1026 |
Genomic view of the SLCO4A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.