This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for SLC9A7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC9A7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC9A7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:46,545,117–46,545,628 | 213.6 kb | Distal (>10kb) Multiome | 641 | |
| chrX:46,573,341–46,574,623 | 185.4 kb | Distal (>10kb) Multiome | 500 | |
| chrX:46,758,820–46,759,807 | 199 bp | At TSS Multiome | 494 | |
| chrX:46,777,921–46,778,647 | 19.1 kb | Distal (>10kb) Multiome | 97 | |
| chrX:46,836,621–46,837,502 | 77.8 kb | Distal (>10kb) Multiome | 606 | |
| chrX:46,903,672–46,904,257 | 144.8 kb | Distal (>10kb) Multiome | 417 | |
| chrX:46,912,095–46,913,434 | 153.4 kb | Distal (>10kb) Multiome | 558 |
Genomic view of the SLC9A7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.