SLC9A1
solute carrier family 9 member A1 | PPP1R143, APNH, NHE-1, NHE1

This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]

Member of: DE-5
Biological processes 94 terms
T-tubule (GO:0030315)antiporter activity (GO:0015297)apical plasma membrane (GO:0016324)basolateral plasma membrane (GO:0016323)basolateral plasma membrane (GO:0016323)basolateral plasma membrane (GO:0016323)calcium ion binding (GO:0005509)calcium-dependent protein binding (GO:0048306)cardiac muscle cell contraction (GO:0086003)cation-transporting ATPase complex (GO:0090533)cell differentiation (GO:0030154)cell migration (GO:0016477)cell surface (GO:0009986)cellular response to acidic pH (GO:0071468)cellular response to acidic pH (GO:0071468)cellular response to antibiotic (GO:0071236)cellular response to cold (GO:0070417)cellular response to electrical stimulus (GO:0071257)cellular response to epinephrine stimulus (GO:0071872)cellular response to hypoxia (GO:0071456)cellular response to insulin stimulus (GO:0032869)cellular response to mechanical stimulus (GO:0071260)cytoplasm (GO:0005737)extracellular exosome (GO:0070062)focal adhesion (GO:0005925)hyaluronan catabolic process (GO:0030214)identical protein binding (GO:0042802)intercalated disc (GO:0014704)intracellular sodium ion homeostasis (GO:0006883)intracellular sodium ion homeostasis (GO:0006883)lamellipodium (GO:0030027)maintenance of cell polarity (GO:0030011)membrane (GO:0016020)membrane (GO:0016020)membrane raft (GO:0045121)membrane raft (GO:0045121)molecular adaptor activity (GO:0060090)monoatomic cation transport (GO:0006812)monoatomic ion transport (GO:0006811)negative regulation of apoptotic process (GO:0043066)perinuclear region of cytoplasm (GO:0048471)phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)phospholipid binding (GO:0005543)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of action potential (GO:0045760)positive regulation of apoptotic process (GO:0043065)positive regulation of calcineurin-NFAT signaling cascade (GO:0070886)positive regulation of cardiac muscle hypertrophy (GO:0010613)positive regulation of cell growth (GO:0030307)positive regulation of intracellular signal transduction (GO:1902533)positive regulation of mitochondrial membrane permeability (GO:0035794)positive regulation of the force of heart contraction (GO:0098735)positive regulation of transcription by RNA polymerase II (GO:0045944)potassium ion transmembrane transport (GO:0071805)potassium:proton antiporter activity (GO:0015386)protein binding (GO:0005515)protein complex oligomerization (GO:0051259)protein phosphatase 2B binding (GO:0030346)protein phosphatase 2B binding (GO:0030346)protein-macromolecule adaptor activity (GO:0030674)proton transmembrane transport (GO:1902600)proton transmembrane transport (GO:1902600)regulation of cardiac muscle cell membrane potential (GO:0086036)regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)regulation of focal adhesion assembly (GO:0051893)regulation of intracellular pH (GO:0051453)regulation of intracellular pH (GO:0051453)regulation of intracellular pH (GO:0051453)regulation of intracellular pH (GO:0051453)regulation of pH (GO:0006885)regulation of pH (GO:0006885)regulation of pH (GO:0006885)regulation of stress fiber assembly (GO:0051492)regulation of the force of heart contraction (GO:0002026)regulation of the force of heart contraction by cardiac conduction (GO:0086092)response to acidic pH (GO:0010447)response to acidic pH (GO:0010447)response to muscle stretch (GO:0035994)sarcolemma (GO:0042383)sodium ion export across plasma membrane (GO:0036376)sodium ion import across plasma membrane (GO:0098719)sodium ion import across plasma membrane (GO:0098719)sodium ion transmembrane transport (GO:0035725)sodium ion transport (GO:0006814)sodium:proton antiporter activity (GO:0015385)sodium:proton antiporter activity (GO:0015385)sodium:proton antiporter activity (GO:0015385)sodium:proton antiporter activity (GO:0015385)sodium:proton antiporter activity (GO:0015385)transmembrane transport (GO:0055085)transporter complex (GO:1990351)
Expression (TPM)
SLC9A1 — as a Regulated Gene

TFs regulating SLC9A1 0 TFs

Transcription factors with Perturb-seq knockdown data for SLC9A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC9A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SLC9A1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC9A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:26,862,775–26,863,565 292.1 kb Distal (>10kb) Multiome 486
chr1:26,864,355–26,865,945 289.9 kb Distal (>10kb) Multiome 892
chr1:26,889,797–26,890,628 264.9 kb Distal (>10kb) Multiome 906
chr1:26,899,986–26,900,610 254.7 kb Distal (>10kb) Multiome 792
chr1:26,913,478–26,914,582 240.8 kb Distal (>10kb) Multiome 877
chr1:26,921,268–26,922,160 233.4 kb Distal (>10kb) Multiome 838
chr1:26,959,908–26,960,855 194.7 kb Distal (>10kb) Multiome 607
chr1:26,992,986–26,995,593 161.5 kb Distal (>10kb) Multiome 854
chr1:26,997,489–26,998,161 157.3 kb Distal (>10kb) Multiome 550
chr1:27,010,686–27,011,820 143.9 kb Distal (>10kb) Multiome 379
chr1:27,012,151–27,013,639 142.1 kb Distal (>10kb) Multiome 712
chr1:27,031,351–27,031,956 123.4 kb Distal (>10kb) Multiome 260
chr1:27,097,474–27,097,686 5.1 kb Proximal (<10kb) 338
chr1:27,102,589–27,103,140 52.2 kb Distal (>10kb) Multiome 263
chr1:27,154,381–27,155,711 13 bp At TSS Multiome 1038
chr1:27,233,894–27,235,362 79.4 kb Distal (>10kb) Multiome 807
chr1:27,321,904–27,322,688 167.0 kb Distal (>10kb) Multiome 1013
chr1:27,349,161–27,350,366 194.7 kb Distal (>10kb) Multiome 573
chr1:27,350,548–27,351,814 196.2 kb Distal (>10kb) Multiome 387
chr1:27,357,379–27,358,028 202.5 kb Distal (>10kb) Multiome 449
chr1:27,360,338–27,361,256 205.4 kb Distal (>10kb) Multiome 170
chr1:27,365,152–27,367,350 211.7 kb Distal (>10kb) Multiome 748
chr1:27,382,910–27,383,795 228.2 kb Distal (>10kb) Multiome 234
chr1:27,391,473–27,393,056 237.4 kb Distal (>10kb) Multiome 700

Genome Browser

Genomic view of the SLC9A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:26,852,775 – 27,403,056
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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