The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for SLC6A9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC6A9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC6A9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:43,933,385–43,935,511 | 97.6 kb | Distal (>10kb) Multiome | 565 | |
| chr1:43,935,659–43,937,001 | 94.6 kb | Distal (>10kb) Multiome | 359 | |
| chr1:43,946,199–43,947,337 | 84.7 kb | Distal (>10kb) Multiome | 1003 | |
| chr1:43,969,717–43,970,284 | 61.4 kb | Distal (>10kb) Multiome | 515 | |
| chr1:43,974,246–43,975,571 | 56.5 kb | Distal (>10kb) Multiome | 875 | |
| chr1:43,978,661–43,979,381 | 52.3 kb | Distal (>10kb) Multiome | 419 | |
| chr1:43,991,242–43,992,448 | 39.5 kb | Distal (>10kb) Multiome HiCAR | 780 | |
| chr1:44,029,597–44,032,070 | 349 bp | At TSS Multiome | 896 | |
| chr1:44,036,004–44,036,357 | 4.6 kb | Proximal (<10kb) | 452 | |
| chr1:44,036,518–44,036,833 | 5.2 kb | Proximal (<10kb) | 318 | |
| chr1:44,213,251–44,213,777 | 182.1 kb | Distal (>10kb) Multiome | 1062 | |
| chr1:44,238,024–44,238,695 | 207.0 kb | Distal (>10kb) Multiome | 396 |
Genomic view of the SLC6A9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.