The protein encoded by this gene is a plasma membrane anion exchange protein. The encoded protein has been found in brain, heart, kidney, small intestine, and lung. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for SLC4A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC4A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC4A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:219,386,994–219,389,117 | 239.4 kb | Distal (>10kb) Multiome | 911 | |
| chr2:219,402,761–219,403,203 | 224.6 kb | Distal (>10kb) Multiome | 234 | |
| chr2:219,418,154–219,419,089 | 208.9 kb | Distal (>10kb) Multiome | 147 | |
| chr2:219,433,920–219,435,459 | 193.4 kb | Distal (>10kb) Multiome | 315 | |
| chr2:219,441,439–219,442,557 | 185.7 kb | Distal (>10kb) Multiome | 338 | |
| chr2:219,447,946–219,449,531 | 178.8 kb | Distal (>10kb) Multiome | 244 | |
| chr2:219,476,330–219,477,528 | 150.8 kb | Distal (>10kb) Multiome | 373 | |
| chr2:219,484,139–219,485,299 | 142.7 kb | Distal (>10kb) Multiome | 146 | |
| chr2:219,497,658–219,499,313 | 128.9 kb | Distal (>10kb) Multiome | 907 | |
| chr2:219,506,707–219,507,641 | 120.5 kb | Distal (>10kb) Multiome | 205 | |
| chr2:219,509,036–219,510,612 | 117.5 kb | Distal (>10kb) Multiome | 614 | |
| chr2:219,521,083–219,521,760 | 106.2 kb | Distal (>10kb) Multiome | 325 | |
| chr2:219,522,621–219,523,337 | 104.6 kb | Distal (>10kb) Multiome | 201 | |
| chr2:219,525,558–219,526,393 | 101.6 kb | Distal (>10kb) Multiome | 321 | |
| chr2:219,530,046–219,530,655 | 97.3 kb | Distal (>10kb) Multiome | 480 | |
| chr2:219,541,583–219,542,284 | 85.8 kb | Distal (>10kb) Multiome | 764 | |
| chr2:219,542,939–219,544,543 | 83.7 kb | Distal (>10kb) Multiome | 981 | |
| chr2:219,551,360–219,553,449 | 75.1 kb | Distal (>10kb) Multiome | 785 | |
| chr2:219,570,096–219,572,421 | 56.0 kb | Distal (>10kb) Multiome | 948 | |
| chr2:219,597,186–219,598,527 | 29.6 kb | Distal (>10kb) Multiome | 955 | |
| chr2:219,627,103–219,628,325 | 119 bp | At TSS Multiome | 315 | |
| chr2:219,642,343–219,643,046 | 15.0 kb | Distal (>10kb) Multiome | 686 | |
| chr2:219,684,717–219,685,631 | 57.6 kb | Distal (>10kb) Multiome | 403 | |
| chr2:219,851,082–219,852,434 | 223.8 kb | Distal (>10kb) Multiome | 229 | |
| chr2:219,916,235–219,917,518 | 289.4 kb | Distal (>10kb) Multiome | 79 |
Genomic view of the SLC4A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.