This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for SLC4A10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC4A10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC4A10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:161,159,952–161,161,374 | 264.0 kb | Distal (>10kb) Multiome | 1083 | |
| chr2:161,237,151–161,239,873 | 185.5 kb | Distal (>10kb) Multiome | 760 | |
| chr2:161,244,441–161,245,204 | 179.6 kb | Distal (>10kb) Multiome | 383 | |
| chr2:161,307,935–161,309,054 | 115.9 kb | Distal (>10kb) Multiome | 1018 | |
| chr2:161,413,932–161,417,535 | 9.7 kb | Proximal (<10kb) Multiome | 691 | |
| chr2:161,417,732–161,419,279 | 5.5 kb | Proximal (<10kb) Multiome | 374 | |
| chr2:161,421,806–161,422,147 | 2.2 kb | Proximal (<10kb) | 12 | |
| chr2:161,422,463–161,424,682 | 408 bp | At TSS Multiome | 296 | |
| chr2:161,426,467–161,428,505 | 2.1 kb | Proximal (<10kb) | 275 | |
| chr2:161,616,339–161,617,240 | 7.2 kb | Proximal (<10kb) | 21 | |
| chr2:161,621,748–161,621,888 | 2.6 kb | Proximal (<10kb) | 12 | |
| chr2:161,623,968–161,626,253 | 200.4 kb | Distal (>10kb) Multiome | 318 |
Genomic view of the SLC4A10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.