Enables choline transmembrane transporter activity. Involved in choline transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC44A5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC44A5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC44A5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:75,314,874–75,316,547 | 295.2 kb | Distal (>10kb) Multiome | 197 | |
| chr1:75,587,198–75,588,494 | 23.2 kb | Distal (>10kb) Multiome | 154 | |
| chr1:75,614,480–75,617,289 | 3.7 kb | Proximal (<10kb) Multiome | 747 | |
| chr1:75,723,970–75,725,189 | 113.5 kb | Distal (>10kb) Multiome | 977 | |
| chr1:75,785,522–75,786,824 | 175.1 kb | Distal (>10kb) Multiome | 835 |
Genomic view of the SLC44A5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.